How Trulance works

Trulance replicates what bodies may do naturally*

Trulance is the only medication for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) that is nearly identical to uroguanylin, a peptide (building block of protein) that occurs naturally in your body. To best understand how uroguanylin works, let’s take a closer look at what happens in your body during the process of digestion.

  1. After you eat, food is broken down in the stomach and the intestines
  2. In the digestion process, fluid helps to form the consistency of the stool created from the waste that's left behind
  3. When there is too little fluid, it may result in constipation, while too much may result in diarrhea
  4. Uroguanylin works best in the small intestine, where—based on the changing pH levels—it provides the right amount of fluid to create well-formed stool*
  5. Uroguanylin has also been shown to reduce stomach pain*
     

    *This activity was seen in animal studies. The relevance to humans is not yet known.

    Pronounced “yur-oh-gwah-nih-lin.”

How do Trulance and uroguanylin differ?

Trulance is very similar to naturally occurring uroguanylin, with exception of a single small molecular difference that improves how Trulance attaches in the small intestine.

Where in the body does Trulance work?

Trulance is thought to work primarily in the small intestine.*

 

*This activity was seen in animal studies. The relevance to humans is not yet known.